This is a revised version of the Hubble Space Telescope Fine Guidance Sensor Instrument Handbook. The main goal of this edition is to help the potential General Observer (GO) learn how to most efficiently use the Fine Guidance Sensors (FGS's). First, the actual performance of the FGS's as scientific instruments is reviewed. Next, each of the available operating modes of the FGS's are reviewed in turn. The status and findings of pertinent calibrations, including Orbital Verification, Science Verification, and Instrument Scientist Calibrations are included as well as the relevant data reduction software.